1-吡咯烷-1-环己烯合成路线 （共 146 条）
反应条件
1: 2.) water / 1.) 1,4-dioxane, reflux, 14 h, 2.) reflux, 1 h
2: 72 percent / water / RuH2(PPh3)4 / 1,2-dimethoxy-ethane / 24 h / 120 °C
View Scheme
参考文献
Murahashi, Shun-Ichi; Sasao, Shigehiro; Saito, Eiichiro; Naota, Takeshi
Tetrahedron, 1993 , vol. 49, # 39 p. 8805 - 8826
反应条件
in 1,4-dioxane
3 h; Heating; Yield given;
参考文献
El-Barbary, A. A.; Carlsson, S.; Lawesson, S.-O.
Tetrahedron, 1982 , vol. 38, # 3 p. 405 - 412
反应条件
in 1,4-dioxane
Addition; 4 h; Heating;
参考文献
Posner, Gary H.; Maxwell, John P.; O'Dowd, Hardwin; Krasavin, Mikhail; Xie, Suji; Shapiro, Theresa A.
Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 6 p. 1361 - 1370
反应条件
acrylic acid methyl ester
参考文献
Stork; Landesman
Journal of the American Chemical Society, 1956 , vol. 78, p. 5128
反应条件
reagiert analog mit 1-Pyrrolidino-cyclopent-1-en;
参考文献
Audier, H. E.; Bouchoux, G.; Fetizon, M.; Jaudon, P.; Tabet J. C.
Tetrahedron, 1981 , vol. 37, # 18 p. 3121 - 3130
反应条件
Erhitzen des Reaktionsprodukts mit Essigsaeure und Natriumacetat;
参考文献
Stork; Landesman
Journal of the American Chemical Society, 1956 , vol. 78, p. 5128
反应条件
1: (i) NaOEt, dioxane, (ii) (hydrolysis), (iii) aq. HCl
2: O2 / Pd / dimethylformamide; H2O
3: KOCMe2Et / toluene
View Scheme
参考文献
Tsuji,J. et al.
Journal of the American Chemical Society, 1979 , vol. 101, p. 5070 - 5072
反应条件
1: 31 percent / toluene / 18 h / Heating
2: 96 percent / glacial acetic acid, water / 0.25 h / 65 °C
View Scheme
参考文献
Moeller, Kevin D.; Tinao, Luzviminda V.
Journal of the American Chemical Society, 1992 , vol. 114, # 3 p. 1033 - 1041
反应条件
in 1,4-dioxane
Reflux;
参考文献
GLAXO GROUP LIMITED; BERTINATO, Peter; FICHMAN, Merav; GHOSH, Shomir; LIN, Jian; SEGAL, Dalia; ZHANG, Zhaoda
Patent: WO2010/49366 A1, 2010 ;
Location in patent: Page/Page column 45; 69 ;
WO 2010/049366 A1
反应条件
multistep reaction; also with hydrolysis; MechanismProduct distribution;
参考文献
Gingrich, Henry L.; Huang, Qiurong; Morales, Angel L.; Jones, Maitland
Journal of Organic Chemistry, 1992 , vol. 57, # 14 p. 3803 - 3806
