N*6*-(4-氟-苄基)-吡啶-2,3 ,6-三胺合成路线 （共 8 条）
反应条件
in tetrahydrofuran Ambient temperature; Yield given;
参考文献
Schwoch; Kramer; Neidlein; Suschitzky
Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2175 - 2190
参考文献
Emig; Nickel; Weischer; Szelenyi; Engel
Arzneimittel-Forschung/Drug Research, 1993 , vol. 43, # 6 p. 627 - 631
反应条件
1: triethylamine / dioxane
2: H2 / Raney nickel / dioxane / 50 °C / 3750.3 Torr
View Scheme
参考文献
Seydel; Schaper; Coats; Cordes
Journal of Medicinal Chemistry, 1994 , vol. 37, # 19 p. 3016 - 3022
反应条件
1: ammonia
2: triethylamine / dioxane
3: H2 / Raney nickel / dioxane / 50 °C / 3750.3 Torr
View Scheme
参考文献
Seydel; Schaper; Coats; Cordes
Journal of Medicinal Chemistry, 1994 , vol. 37, # 19 p. 3016 - 3022
反应条件
sodium dithionite in tetrahydrofuran; water
Ambient temperature;
参考文献
Schwoch; Kramer; Neidlein; Suschitzky
Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2175 - 2190
反应条件
1: 41.8 percent / propan-2-ol / 71 h / Heating
2: 52.8 percent / MnO2 / tetrahydrofuran / 18 h / Ambient temperature
3: Na2S2O4 / tetrahydrofuran; H2O / Ambient temperature
View Scheme
参考文献
Schwoch; Kramer; Neidlein; Suschitzky
Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2175 - 2190
反应条件
1: 52.8 percent / MnO2 / tetrahydrofuran / 18 h / Ambient temperature
2: Na2S2O4 / tetrahydrofuran; H2O / Ambient temperature
View Scheme
参考文献
Schwoch; Kramer; Neidlein; Suschitzky
Helvetica Chimica Acta, 1994 , vol. 77, # 8 p. 2175 - 2190
反应条件
2: H2 / Raney nickel
View Scheme
参考文献
Emig; Nickel; Weischer; Szelenyi; Engel
Arzneimittel-Forschung/Drug Research, 1993 , vol. 43, # 6 p. 627 - 631
