3-(6-氯咪唑并[1,2-b]吡嗪-2-基)苯甲腈合成路线 （共 4 条）
反应条件
in ethanol 12 h; Heating / reflux;
参考文献
Hutchison Medipharma Enterprises Limited
Patent: US2009/118292 A1, 2009 ;
Location in patent: Page/Page column 17; 27 ;
反应条件
1: bromine / diethyl ether / 4 h / 0 - 20 °C 2: ethanol / 10 h / Reflux View Scheme
反应条件
1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol / 5 h / 20 °C 2: hydroxylamine hydrochloride; triethylamine / ethanol / 4 h / Reflux View Scheme
参考文献
HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DENG, Wei; CAI, Yu; DUAN, Jifeng
Patent: WO2011/137587 A1, 2011 ;
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran; methanol T=20°C; 4 - 6 h; Product distribution / selectivity;
参考文献
Hutchison Medipharma Enterprises Limited
Patent: US2009/118292 A1, 2009 ;
Location in patent: Page/Page column 17; 27 ;
