4-(4-(4-硝基苯基)-1-哌嗪基)苯酚合成路线 （共 14 条）
反应条件
N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one T=120 - 125°C; 5 - 7 h;
参考文献
Schering Corporation
Patent: EP1230231 B1, 2005 ;
Location in patent: Page/Page column 4 ;
反应条件
potassium carbonate in N,N-dimethyl acetamide; water
参考文献
Janssen Pharmaceutica, N.V.
Patent: US4791111 A1, 1988 ;
反应条件
hydrogen bromide in water 24 h; Heating;
参考文献
Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh; Shen, Lan; Anderson Evans; Goodman, Andrew
Tetrahedron Letters, 2002 , vol. 43, # 18 p. 3359 - 3363
反应条件
1: 77 percent / K2CO3; TBAI / dimethylsulfoxide / Heating 2: 80 percent / HBr / H2O / 24 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 18 p. 3359 - 3363
反应条件
1: With sulfuric acid; sodium nitrite Diazotization; 2: With copper(I) oxide; copper(II) nitrate in water Hydrolysis;
参考文献
Hepperle, Michael; Eckert, Jeffrey; Gala, Dinesh
Tetrahedron Letters, 1999 , vol. 40, # 31 p. 5655 - 5659
反应条件
1.1: 76 percent / potassium carbonate / dimethylsulfoxide / Heating 2.1: 95 percent / NH4O2CH / Pd/C / methanol / Heating 3.1: 77 percent / potassium carbonate; tetra-N-butylammonium iodide / dimethylsulfoxide / Heating 4.1: NaNO2; H2SO4 4.2: 48 percent / Cu(NO3)2; Cu2O / H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 31 p. 5655 - 5659
反应条件
1.1: 95 percent / NH4O2CH / Pd/C / methanol / Heating 2.1: 77 percent / potassium carbonate; tetra-N-butylammonium iodide / dimethylsulfoxide / Heating 3.1: NaNO2; H2SO4 3.2: 48 percent / Cu(NO3)2; Cu2O / H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 31 p. 5655 - 5659
反应条件
1.1: 91 percent / potassium carbonate; tetra-N-butylammonium iodide / dimethylsulfoxide / 12 h / 120 °C 2.1: 95 percent / NH4O2CH / Pd/C / methanol / Heating 3.1: 77 percent / potassium carbonate; tetra-N-butylammonium iodide / dimethylsulfoxide / Heating 4.1: NaNO2; H2SO4 4.2: 48 percent / Cu(NO3)2; Cu2O / H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 31 p. 5655 - 5659
反应条件
1: 82 percent / (+)-BINAP; NaOt-Bu / Pd2(dba)3 / toluene; tetrahydrofuran / 24 h / 80 - 90 °C 2: 77 percent / K2CO3; TBAI / dimethylsulfoxide / Heating 3: 80 percent / HBr / H2O / 24 h / Heating View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 18 p. 3359 - 3363
反应条件
1.1: 77 percent / potassium carbonate; tetra-N-butylammonium iodide / dimethylsulfoxide / Heating 2.1: NaNO2; H2SO4 2.2: 48 percent / Cu(NO3)2; Cu2O / H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 31 p. 5655 - 5659
