1: 2-picoline With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: cyclobutanecarboxylic acid N-methoxy-N-methylamide in tetrahydrofuran; hexane T=-78°C; 3 h; Inert atmosphere;

1.1: tetrahydrofuran / 0.08 h / -20 °C / |Inert atmosphere 1.2: 0.42 h / -20 °C / |Inert atmosphere 2.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / |Inert atmosphere 2.2: 3 h / -78 °C / |Inert atmosphere View Scheme