(6-溴吡啶-2-基)乙腈合成路线 （共 8 条）
反应条件
1: acetonitrile With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.75 h; 2: 2,6-Dibromopyridine in tetrahydrofuran; hexane T=-78 - 20°C; Alkylation; 2.5 h;
参考文献
Skerlj; Bogucki; Bridger
Synlett, 2000 , # 10 p. 1488 - 1490
反应条件
in 1,4-dioxane; water T=0 - 20°C; 16 h;
参考文献
APPLIED RESEARCH SYSTEMS ARS HOLDING N. V.
Patent: WO2004/98607 A1, 2004 ;
Location in patent: Page/Page column 43-44 ;
WO 2004/098607 A1
反应条件
18-crown-6 ether in acetonitrile 5 h; Heating / reflux;
参考文献
WO2005/14566 A1, ;
Page/Page column 87 ;
反应条件
1: With toluene-4-sulfonic acid in toluene 12 h; Reflux; 2: With sodium hydrogencarbonate; sodium sulfate in water; toluene
参考文献
Farahat; Boykin
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 3 p. 585 - 589
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 80 °C / |Inert atmosphere 1.2: pH 1 / |Inert atmosphere; |Cooling with ice 2.1: toluene-4-sulfonic acid / toluene / 12 h / |Reflux View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 50, # 3 p. 585 - 589
反应条件
sodium carbonate; triphenylphosphine in methanol; toluene
T=80°C; Suzuki Coupling; 24 h; Inert atmosphere;
参考文献
Farahat; Boykin
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 3 p. 585 - 589
反应条件
boron trifluoride-tetrahydrofuran complex in tetrahydrofuran
T=60°C; 18 h;
参考文献
Skerlj, Renato T.; Zhou, Yuanxi; Wilson, Trevor; Bridger, Gary J.
Journal of Organic Chemistry, 2002 , vol. 67, # 4 p. 1407 - 1410
反应条件
1: BF3*THF / tetrahydrofuran / 18 h / 60 °C
2: 6.3 g / Et3N / CH2Cl2 / 20 °C
View Scheme
参考文献
Skerlj, Renato T.; Zhou, Yuanxi; Wilson, Trevor; Bridger, Gary J.
Journal of Organic Chemistry, 2002 , vol. 67, # 4 p. 1407 - 1410
