反应条件
1: 76 percent / K2CO3 / ethanol / 72 h / Ambient temperature
2: 61 percent / LiAlH4 / tetrahydrofuran / 18 h / Heating
3: 1.) DMSO, (COCl)2, 2.) Et3N / 1.) CH2Cl2, from -65 deg C to -60 deg C, 15 min, 2.) CH2Cl2, from -78 deg C to RT, 6 h
4: 1.) LDA / 1.) THF, -20 deg C, 35 min, 2.) THF, from -40 deg C to RT, 21 h
5: 78 percent / 4N aq. HCl / tetrahydrofuran / 17 h / Ambient temperature
View Scheme
参考文献
Gilligan; Cain; Christos; Cook; Drummond; Johnson; Kergaye; McElroy; Rohrbach; Schmidt; Tam
Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4344 - 4361
