1-溴-2-氯-4-甲基-5-硝基苯合成路线 (共 2 条)
反应条件
sulfuric acid; nitric acid in water T=-20 - 25°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/27746 A1, 2009 ;
Location in patent: Page/Page column 80 ;
WO 2009/027746 A1
反应条件
1: With FeCl3 adsorbed on SiO2 in methanol T=70°C; 0.25 h; 2: With hydrazine in methanol; water Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/27746 A1, 2009 ;
Location in patent: Page/Page column 80 ;
WO 2009/027746 A1