sodium methylate in methanol T=60°C; 3 h; Inert atmosphere;

1: sodium methylate / methanol 2: triethylamine / dichloromethane / 2.17 h 3: hydrogenchloride / trans-1,3-dioxane / 24 h / 20 °C 4: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C View Scheme