3-(2-吗啉-4-基乙氧基)苯胺合成路线 （共 7 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol T=20°C; P=2585.81 Torr; 1 h;
参考文献
RIGEL PHARMACEUTICALS, INC.
Patent: WO2007/30680 A2, 2007 ;
Location in patent: Page/Page column 152-153 ;
WO 2007/030680 A2
反应条件
1: N-(2-hydroxy-ethyl)-morpholine; 3-amino-phenol With triphenylphosphine on polystyrene; di-tert-butylazodicarboxylate in tetrahydrofuran T=20°C; 15 h; Polystyrene; 2: trifluoroacetic acid in tetrahydrofuran T=20°C; 1 h; 3: With water; sodium hydrogencarbonate in ethyl acetate
参考文献
SmithKline Beecham Corporation
Patent: US2008/51395 A1, 2008 ;
Location in patent: Page/Page column 54 ;
US 20080051395 A1
反应条件
1: 3-amino-phenol With potassium carbonate in ethanol T=60°C; 6 h; 2: 2-chloroethyl-morpholine 7 h; Heating / reflux;
参考文献
EP1027342 B1, ;
Page 18 ;
反应条件
sodium hydroxide in hydrogenchloride; N,N-dimethyl-formamide
参考文献
US2002/13352 A1, ;
US 20020013352 A1
反应条件
1: potassium carbonate; potassium iodide / acetone / 11 h / |Reflux 2: sodium hydroxide; water / ethanol / 7 h / |Reflux View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 62, # 8 p. 360 - 366
反应条件
1: potassium carbonate; potassium iodide / acetone / 11 h / |Reflux 2: sodium hydroxide; water / ethanol / 7 h / |Reflux View Scheme
参考文献
Arzneimittel-Forschung/Drug Research, , vol. 62, # 8 p. 360 - 366
