1.1: N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere 1.2: -78 - 20 °C 2.1: N,N,N',N',N'',N''-hexamethylphosphoric triamide; diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 - 20 °C / Inert atmosphere 3.1: potassium hydroxide; water / methanol / 24 h / Reflux 3.2: pH 3 4.1: sodium hydroxide / water; acetone 5.1: bromine / hexane / 1 h / 20 °C 6.1: sodium hydroxide; water / 24 h / Reflux View Scheme

1: bromine / hexane / 1 h / 20 °C 2: sodium hydroxide; water / 24 h / Reflux View Scheme

in methanol; hexane T=20°C; 2 h;

暂无反应条件数据

(i) NaH, 1,2-dimethoxyethane, (ii) /BRN= 969135/; Multistep reaction;