8-羟基喹啉-N-氧化物合成路线 （共 25 条）
反应条件
water; nitric acid; acetic acid konz. wss. Salpetersaeure;
参考文献
Petrow; Sturgeon
Journal of the Chemical Society, 1954 , p. 570,572
反应条件
1: With dimethyl sulfate in acetonitrile T=80°C; 2: With ammonia in water T=-25 - -15°C;
参考文献
Nayak, Pabitra K.; Agarwal, Neeraj; Ali, Farman; Patankar, Meghan P.; Narasimhan; Periasamy
Journal of Chemical Sciences, 2010 , vol. 122, # 6 p. 847 - 855
反应条件
1.1: 2.5 h / 70 °C / Cooling with ice 2.1: AlCl3, aluminium chloride / anhydrous dichloroethane / 3 h / 80 °C / Cooling with ice 2.2: 20 °C View Scheme
参考文献
TEIJIN PHARMA LIMITED
Patent: US2012/46467 A1, 2012 ;
反应条件
1: CCl4 2: H2O View Scheme
参考文献
Shrader, William D.; Celebuski, Joseph; Kline, Steven J.; Johnson, David
Tetrahedron Letters, 1988 , vol. 29, # 12 p. 1351 - 1354
反应条件
dimethyl sulfate Yield given. Multistep reaction;
参考文献
Rao, A. V. Rama; Chavan, Subhash P.; Sivadasan, Latha
Tetrahedron, 1986 , vol. 42, # 18 p. 5065 - 5071
反应条件
1: 39 percent / 5 h / 140 °C 2: 93 percent / K2CO3 / methanol / 1 h / 20 °C View Scheme
参考文献
Sigouin, Olivier; Beauchamp, Andre L.
Canadian Journal of Chemistry, 2005 , vol. 83, # 5 p. 460 - 470
参考文献
Petitjean, Anne; Kyritsakas, Nathalie; Lehn, Jean-Marie
Chemistry - A European Journal, 2005 , vol. 11, # 23 p. 6818 - 6828
参考文献
Moran, Edmund J.; Jacobsen, John R.; Aggen, James B.
Patent: US2003/153597 A1, 2003 ;
反应条件
1.1: 2.5 h / 70 °C / Cooling with ice 2.1: AlCl3, aluminium chloride / anhydrous dichloroethane / 3 h / 80 °C / Cooling with ice 2.2: 20 °C 3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C 4.1: pyridinium tribromide / tetrahydrofuran / 0 °C / Reflux View Scheme
参考文献
TEIJIN PHARMA LIMITED
Patent: US2012/46467 A1, 2012 ;
反应条件
1: 39 percent / 5 h / 140 °C 2: 93 percent / K2CO3 / methanol / 1 h / 20 °C 3: 41 percent / POCl3 / 1 h / Heating View Scheme
参考文献
Sigouin, Olivier; Beauchamp, Andre L.
Canadian Journal of Chemistry, 2005 , vol. 83, # 5 p. 460 - 470
