2,4-二氯-5,6,7,8-四氢喹唑啉合成路线 （共 13 条）
参考文献
European Journal of Medicinal Chemistry, , vol. 15, # 4 p. 317 - 322
反应条件
N,N-diethylaniline; trichlorophosphate 24 h; Reflux;
参考文献
NEUROGEN CORPORATION; SCHERING CORPORATION
Patent: EP1025097 B1, 2005 ;
Location in patent: Page/Page column 14 ;
反应条件
1: ethanol / 5 h / 160 °C 2: POCl3 / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 22 p. 3828 - 3833
反应条件
1: 75 percent / aqu. ammonia / ethanol / 100 °C
2: 35 percent / N-methylmorpholine / 3-methyl-butan-1-ol / 5 h / 180 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: 75 percent / aqu. ammonia / ethanol / 100 °C
2: 58 percent / N-methylmorpholine / 3-methyl-butan-1-ol / 5 h / 180 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: 75 percent / aqu. ammonia / ethanol / 100 °C
2: 85 percent / N-methylmorpholine / 3-methyl-butan-1-ol / 5 h / 180 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: 83 percent / tetrahydrofuran; H2O / Ambient temperature
2: 3-methyl-butan-1-ol / 4 h / Heating
3: 10 percent hydrochloric acid / 1 h / 100 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: 59 percent / tetrahydrofuran; H2O / Ambient temperature
2: 3-methyl-butan-1-ol / 4 h / Heating
3: 10 percent hydrochloric acid / 1 h / 100 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: 49 percent / tetrahydrofuran; H2O / Ambient temperature
2: 3-methyl-butan-1-ol / 4 h / Heating
3: 10 percent hydrochloric acid / 1 h / 100 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
反应条件
1: 47 percent / tetrahydrofuran; H2O / Ambient temperature
2: 3-methyl-butan-1-ol / 4 h / Heating
3: 10 percent hydrochloric acid / 1 h / 100 °C
View Scheme
参考文献
Sekiya; Hiranuma; Kanayama; Hata
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 4 p. 317 - 322
