(2E)-3-(2-氯苯基)-2-[4-氟(14C6)苯基]丙烯醛合成路线 （共 7 条）
反应条件
sodium hydroxide in methanol; water T=15 - 25°C; 3 - 5 h;
参考文献
WO2005/56498 A2, ;
Page/Page column 11-13 ;
反应条件
1: With sodium hydroxide in methanol T=20 - 30°C; 9 - 10 h; 2: With sulfuric acid in methanol; water pH=7;
参考文献
WO2005/56498 A2, ;
Page/Page column 13; 14 ;
反应条件
1: 2-chloro-benzyl chloride With ethyl bromide; magnesium in diethyl ether T=25 - 35°C; 2: 1,1-dimethoxy-2-(4-fluorophenyl)-ethan-2-one in diethyl ether; toluene T=0 - 5°C; Grignard Reaction; 2 h;
参考文献
US2011/295019 A1, ;
Page/Page column 7 ;
反应条件
1: HCl / methanol; toluene 2: sodium methylate / dimethylformamide / 3 h / Ambient temperature View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 38, # 2 p. 173 - 178
反应条件
sodium methylate in N,N-dimethyl-formamide 3 h; Ambient temperature;
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 38, # 2 p. 173 - 178
反应条件
1.1: potassium tert-butylate / N,N-dimethyl-formamide / 40 - 110 °C / Inert atmosphere 1.2: 100 - 110 °C / Inert atmosphere 2.1: hydrogenchloride; water / methanol / 0.5 h View Scheme
反应条件
1.1: potassium tert-butylate / methanol / 0.5 h / 5 - 10 °C 1.2: 2 h / 65 °C 2.1: hydrogenchloride; water / methanol / 0.5 h View Scheme
