1: 4-Bromo-2-fluorobenzoic acid With thionyl chloride in benzene
Heating / reflux;
2: diethylamine With sodium hydroxide in dichloromethane; water
1 h;
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2004/35574 A2, 2004 ;
Location in patent: Page 27 ;
WO 2004/035574 A2