4-溴-2-氟苯甲酸合成路线

参考文献

CHEMIZON, A DIVISION OF OPTOMAGIC CO., LTD.
Patent: US2012/53180 A1, 2012 ;
Location in patent: Page/Page column 29 ;
US 20120053180 A1

1993-03-92-氟苯硼酸+

112704-79-74-溴-2-氟苯甲酸

505082-83-7

参考文献

Choi, Jun Yong; Calvet, Claudia M.; Gunatilleke, Shamila S.; Ruiz, Claudia; Cameron, Michael D.; McKerrow, James H.; Podust, Larissa M.; Roush, William R.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 19 p. 7651 - 7668

3900-89-82-氯苯基硼酸+

112704-79-74-溴-2-氟苯甲酸

505082-99-52-氯-3-氟-[1,1-联苯]-4-羧酸

参考文献

Choi, Jun Yong; Calvet, Claudia M.; Gunatilleke, Shamila S.; Ruiz, Claudia; Cameron, Michael D.; McKerrow, James H.; Podust, Larissa M.; Roush, William R.
Journal of Medicinal Chemistry, 2013 , vol. 56, # 19 p. 7651 - 7668

112704-79-74-溴-2-氟苯甲酸+

73183-34-3联硼酸频那醇酯

603122-52-73-氟-4-甲氧基羰基苯硼酸频那醇酯

参考文献

FUJISAWA PHARMACEUTICAL CO., LTD.
Patent: US2004/6143 A1, 2004 ;
US 20040006143 A1

925-90-6乙基溴化镁+

112704-79-74-溴-2-氟苯甲酸

644984-78-14-溴-2-乙基苯甲酸

参考文献

Hammond, Marlys; Washburn, David G.; Hoang, Tram H.; Manns, Sharada; Frazee, James S.; Nakamura, Hiroko; Patterson, Jaclyn R.; Trizna, Walter; Wu, Charlene; Azzarano, Leonard M.; Nagilla, Rakesh; Nord, Melanie; Trejo, Rebecca; Head, Martha S.; Zhao, Baoguang; Smallwood, Angela M.; Hightower, Kendra; Laping, Nicholas J.; Schnackenberg, Christine G.; Thompson, Scott K.
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4441 - 4445

112704-79-74-溴-2-氟苯甲酸

644984-78-14-溴-2-乙基苯甲酸

参考文献

Dow AgroSciences LLC; Lo, William C.; Hunter, James E.; Watson, Gerald B.; Patny, Akshay; Iyer, Pravin S.; Boruwa, Joshodeep
Patent: US2014/171308 A1, 2014 ;
Location in patent: Page/Page column ;

107-06-2二氯乙烷+

112704-79-74-溴-2-氟苯甲酸

395639-63-1

参考文献

F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; BINGGELI, Alfred; HERTEL, Cornelia; KONKAR, Anish Ashok; KUEHNE, Holger; KUHN, Bernd; MAERKI, Hans P.; WANG, Haiyan
Patent: WO2012/101011 A2, 2012 ;
Location in patent: Page/Page column 53-54 ;

112704-79-74-溴-2-氟苯甲酸

395639-63-1

参考文献

Aebi, Johannes; Binggeli, Alfred; Hertel, Cornelia; Konkar, Anish Ashok; Kuehne, Holger; Kuhn, Bernd; Maerki, Hans P.; Wang, Haiyan
Patent: US2013/18055 A1, 2013 ;