乙基[3-(4-溴-2-氟苄基)-7-氯-2,4-二氧代-3,4-二氢-1(2H)-喹唑啉基]乙酸酯合成路线 （共 6 条）
反应条件
potassium carbonate; acetic acid in methanol; water; acetone
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.
Patent: EP1160243 A1, 2001 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Koay, Natalie; Campeau, Louis-Charles
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 2 p. 473 - 478
反应条件
hydrogenchloride in hexane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4734419 A1, 1988 ;
反应条件
1.1: tetrahydrofuran / Reflux
2.1: hydrogenchloride / ethanol / 70 °C
2.2: 5 °C
3.1: potassium carbonate / N,N-dimethyl-formamide
View Scheme
参考文献
Koay, Natalie; Campeau, Louis-Charles
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 2 p. 473 - 478
反应条件
1.1: sodium hydroxide / water / 2 h / 60 - 65 °C / pH 6.5 / |Large scale
1.2: 2 h / 30 °C / pH 1 - 1.5 / |Large scale
2.1: potassium carbonate / N,N-dimethyl-formamide
3.1: potassium carbonate / acetone / 5 h / 20 °C / |Reflux; |Large scale
View Scheme
参考文献
Goto, Shunsuke; Tsuboi, Hiroyuki; Kanoda, Masami; Mukai, Koji; Kagara, Kooji
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 700 - 706
反应条件
1: potassium carbonate / N,N-dimethyl-formamide
2: potassium carbonate / acetone / 5 h / 20 °C / |Reflux; |Large scale
View Scheme
参考文献
Goto, Shunsuke; Tsuboi, Hiroyuki; Kanoda, Masami; Mukai, Koji; Kagara, Kooji
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 700 - 706
