7-氯-3,4-二氢-2,4-二氧代-1(2H)-喹唑啉乙酸乙基酯合成路线 （共 9 条）
反应条件
pyridine in tetrahydrofuran; water
参考文献
Sumitomo Chemical Company, Limited
Patent: US5780628 A1, 1998 ;
反应条件
pyridine in tetrahydrofuran; water
参考文献
Sumitomo Chemical Company, Limited
Patent: US5780628 A1, 1998 ;
反应条件
1,1'-carbonyldiimidazole in 1,4-dioxane
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4734419 A1, 1988 ;
反应条件
1: With ethyl bromoacetate in 4-methyl-1,3-dioxolan-2-one
T=125 - 140°C; 6 h;
2: With methanol in 4-methyl-1,3-dioxolan-2-one; ethyl acetate
T=20 - 70°C; 1.5 h;
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US6344559 B1, 2002 ;
Location in patent: Page column 4 ;
反应条件
1.1: sodium hydroxide / water / 2 h / 60 - 65 °C / pH 6.5 / |Large scale
1.2: 2 h / 30 °C / pH 1 - 1.5 / |Large scale
2.1: potassium carbonate / N,N-dimethyl-formamide
View Scheme
参考文献
Goto, Shunsuke; Tsuboi, Hiroyuki; Kanoda, Masami; Mukai, Koji; Kagara, Kooji
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 700 - 706
反应条件
1.1: sodium hydroxide; hydrogenchloride / water / 5 h / 20 - 30 °C / pH 6.5 / |Large scale
2.1: sodium hydroxide / water / 2 h / 60 - 65 °C / pH 6.5 / |Large scale
2.2: 2 h / 30 °C / pH 1 - 1.5 / |Large scale
3.1: potassium carbonate / N,N-dimethyl-formamide
View Scheme
参考文献
Goto, Shunsuke; Tsuboi, Hiroyuki; Kanoda, Masami; Mukai, Koji; Kagara, Kooji
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 700 - 706
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
Goto, Shunsuke; Tsuboi, Hiroyuki; Kanoda, Masami; Mukai, Koji; Kagara, Kooji
Organic Process Research and Development, 2003 , vol. 7, # 5 p. 700 - 706
反应条件
potassium carbonate; acetic acid in methanol; water; acetone
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.
Patent: EP1160243 A1, 2001 ;
反应条件
hydrogenchloride in hexane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4734419 A1, 1988 ;
