(2S,3R)-(+)-N-Boc-6-氧代-2,3-二苯基吗啉合成路线 (共 5 条)
反应条件
toluene-4-sulfonic acid; calcium chloride in benzene 8 h; Heating;
参考文献
Journal of the American Chemical Society, , vol. 110, # 5 p. 1547 - 1557
反应条件
1: p-TsOH / benzene / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 17 p. 6653 - 6660
反应条件
1: Et3N / tetrahydrofuran / 1 h / 20 °C 2: toluene / 10 h / Heating 3: p-TsOH*H2O / toluene View Scheme
参考文献
Synlett, , # 4 art. no. Y04304ST, p. 693 - 696
反应条件
1: NaHCO3, NaCl / CHCl3; H2O / 20 h / Heating 2: p-toluenesulfonic acid monohydrate, CaCl2 / benzene / 8 h / Heating View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 5 p. 1547 - 1557
反应条件
1: With trifluoroacetic acid in dichloromethane T=20°C; 3 h; 2: With triethylamine in dichloromethane T=20°C; 0.333333 h;
参考文献
Ueda, Masafumi; Miyabe, Hideto; Teramachi, Masako; Miyata, Okiko; Naito, Takeaki
Journal of Organic Chemistry, 2005 , vol. 70, # 17 p. 6653 - 6660