4-溴吡啶-2,6-二羧酸二乙酯合成路线 （共 19 条）
反应条件
1: chelidamic acid With phosphorus pentabromide in tetrachloromethane 12 h; Reflux; 2: ethanol in tetrachloromethane T=80°C; 0.5 h;
参考文献
Organic Process Research and Development, , vol. 7, # 1 p. 38 - 43
反应条件
1: chelidamic acid With phosphorus pentabromide T=90°C; 3 h; 2: ethanol
参考文献
WO2006/80022 A2, ;
Page/Page column 28-29; 50 ;
WO 2006/080022 A2
反应条件
1: chelidamic acid With bromine; phosphorus tribromide in chloroform T=20 - 90°C; 2: ethanol in chloroform T=0°C;
参考文献
Arkivoc, , vol. 2011, # 9 p. 77 - 93
反应条件
1: phosphorous pentabromide / 0.5 h / 100 °C 2: 22.0 g / diethyl ether / 0 °C View Scheme
参考文献
Journal of Chemical Crystallography, , vol. 37, # 4 p. 299 - 308
Journal of Chemical Crystallography, , vol. 36, # 6 p. 371 - 379
反应条件
in chloroform Esterification; ice cooling;
参考文献
Tetrahedron, , vol. 54, # 16 p. 4107 - 4124
参考文献
Tetrahedron Letters, , vol. 39, # 23 p. 3999 - 4002
反应条件
1: phosphorus pentabromide / 1.75 h / 90 °C 2: 6.56 g / CHCl3 / ice cooling View Scheme
参考文献
Tetrahedron, , vol. 54, # 16 p. 4107 - 4124
反应条件
1.1: 96 percent / NH4OH / H2O / 5 h / 100 °C 2.1: PBr5 / 2.5 h / 90 °C 2.2: 83 percent / CHCl3 / cooling View Scheme
参考文献
Dalton Transactions, , # 1 p. 153 - 159
反应条件
1.1: 83 percent / HCl / 20 h / 100 °C 2.1: 96 percent / NH4OH / H2O / 5 h / 100 °C 3.1: PBr5 / 2.5 h / 90 °C 3.2: 83 percent / CHCl3 / cooling View Scheme
参考文献
Dalton Transactions, , # 1 p. 153 - 159
反应条件
1: 91 percent / aq. LiOH / tetrahydrofuran / 2.75 h 2: 92 percent / oxalyl chloride; DMF / CH2Cl2 / 20 h / Heating View Scheme
参考文献
Pryor, Kent E.; Shipps Jr., Gerald W.; Skyler, David A.; Rebek Jr., Julius
Tetrahedron, 1998 , vol. 54, # 16 p. 4107 - 4124
