4-溴吡啶-2,6-二羧酸二乙酯合成路线 （共 19 条）
反应条件
hydrazine in ethanol
参考文献
Nettekoven, Matthias; Jenny, Christian
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 38 - 43
反应条件
1: 90 percent / NH2NH2 / ethanol 2: 90 percent / aq. NaNO2; aq. HCl View Scheme
参考文献
Nettekoven, Matthias; Jenny, Christian
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 38 - 43
反应条件
hydrogen; potassium carbonate; palladium on activated charcoal in dichloromethane T=0°C; 1 h;
参考文献
Herdering, Wilhelm; Krueger, Hans-Joerg
Journal of Labelled Compounds and Radiopharmaceuticals, 1998 , vol. 41, # 4 p. 301 - 307
反应条件
lithium hydroxide in tetrahydrofuran Hydrolysis; 2.75 h;
参考文献
Pryor, Kent E.; Shipps Jr., Gerald W.; Skyler, David A.; Rebek Jr., Julius
Tetrahedron, 1998 , vol. 54, # 16 p. 4107 - 4124
反应条件
sodium tetrahydroborate in ethanol room temperature, 2 h -> reflux, 15 h;
参考文献
Takalo, Harri; Pasanen, Paavo; Kankare, Jouko
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1988 , vol. 42, # 6 p. 373 - 377
反应条件
sodium tetrahydroborate in ethanol
参考文献
Isis Pharmaceuticals, Inc.
Patent: US6191273 B1, 2001 ;
反应条件
copper(l) iodide; palladium diacetate; triphenylphosphine in triethylamine T=40 - 50°C; 2 h;
参考文献
Takalo, Harri; Kankare, Jouko
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1987 , vol. 41, # 3 p. 219 - 221
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / toluene
2: potassium carbonate; tris-(dibenzylideneacetone)dipalladium(0); copper(l) chloride / N,N-dimethyl-formamide / 60 °C
View Scheme
参考文献
Hamada, Yoshio; Suzuki, Kenji; Nakanishi, Tomoya; Sarma, Diganta; Ohta, Hiroko; Yamaguchi, Ryoji; Yamasaki, Moe; Hidaka, Koushi; Ishiura, Shoichi; Kiso, Yoshiaki
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 2 p. 618 - 623
反应条件
hydrogen iodide; potassium iodide in water
T=130°C;
参考文献
Pauvert, Mickael; Laine, Patrick; Jonas, Marco; Wiest, Olaf
Journal of Organic Chemistry, 2004 , vol. 69, # 2 p. 543 - 548
