(9ci)-1,5,6-三甲基-1H-苯并咪唑合成路线 （共 6 条）
反应条件
1: 5,6-dimethyl-1H-benzimidazole With sodium hydride in N,N-dimethyl-formamide
T=20°C; 4 h;
2: methyl iodide in N,N-dimethyl-formamide
T=20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/107784 A1, 2006 ;
Location in patent: Page/Page column 48 ;
WO 2006/107784 A1
反应条件
potassium hydroxide; 18-crown-6 ether in tetrachloromethane
30 h; Ambient temperature;
参考文献
Antonini, Ippolito; Cristalli, Gloria; Franchetti, Palmarisa; Grifantini, Mario; Martelli, Sante
Heterocycles, 1982 , vol. 19, # 12 p. 2313 - 2317
反应条件
triethylamine in N,N-dimethyl-formamide
2 h; Heating;
参考文献
Kuz'menko, V. V.; Kuz'menko, T. A.; Simonov, A. M.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 3 p. 282 - 287
Khimiya Geterotsiklicheskikh Soedinenii, 1986 , vol. 22, # 3 p. 346 - 351
反应条件
in dichloromethane
Kinetics; 25.00+/-0.04°C; not isolated; spectrophotometric monitoring;
参考文献
Charland, Jean-Pierre; Attia, Wahib M.; Randaccio, Lucio; Marzilli, Luigi G.
Organometallics, 1990 , vol. 9, p. 1367 - 1375
参考文献
Beaven et al.
Journal of Pharmacy and Pharmacology, 1949 , vol. 1, p. 957,968
反应条件
N,N-dimethyl-formamide
3 h; Heating; Product distribution;
参考文献
Kuz'menko, V. V.; Kuz'menko, T. A.; Simonov, A. M.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1986 , vol. 22, # 3 p. 282 - 287
Khimiya Geterotsiklicheskikh Soedinenii, 1986 , vol. 22, # 3 p. 346 - 351
