4,5-二甲基-3-羟基甲苯合成路线 （共 21 条）
反应条件
1: 100 percent / LiAlH4 / diethyl ether / 0.25 h / 60 °C
2: 95 percent / H2 / Pd/C / methanol / 20 °C / atmospheric pressure
View Scheme
参考文献
Takenaka, Yukiko; Tanahashi, Takao; Nagakura, Naotaka; Hamada, Nobuo
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 7 p. 794 - 797
反应条件
1: NaBr; oxone / acetone; H2O
2: K2CO3 / acetone / 45 °C
3: 100 percent / MCPA; p-TsOH / CHCl3 / 3 h / 50 °C
4: Na / methanol / 20 °C
5: CuBr / dimethylformamide; H2O / 130 °C
View Scheme
参考文献
Bovicelli, Paolo; Antonioletti, Roberto; Barontini, Maurizio; Borioni, Giorgio; Bernini, Roberta; Mincione, Enrico
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1255 - 1257
反应条件
1: K2CO3 / acetone / 45 °C
2: 100 percent / MCPA; p-TsOH / CHCl3 / 3 h / 50 °C
3: Na / methanol / 20 °C
4: CuBr / dimethylformamide; H2O / 130 °C
View Scheme
参考文献
Bovicelli, Paolo; Antonioletti, Roberto; Barontini, Maurizio; Borioni, Giorgio; Bernini, Roberta; Mincione, Enrico
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1255 - 1257
反应条件
1: 100 percent / MCPA; p-TsOH / CHCl3 / 3 h / 50 °C
2: Na / methanol / 20 °C
3: CuBr / dimethylformamide; H2O / 130 °C
View Scheme
参考文献
Bovicelli, Paolo; Antonioletti, Roberto; Barontini, Maurizio; Borioni, Giorgio; Bernini, Roberta; Mincione, Enrico
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1255 - 1257
反应条件
1: Na / methanol / 20 °C
2: CuBr / dimethylformamide; H2O / 130 °C
View Scheme
参考文献
Bovicelli, Paolo; Antonioletti, Roberto; Barontini, Maurizio; Borioni, Giorgio; Bernini, Roberta; Mincione, Enrico
Tetrahedron Letters, 2005 , vol. 46, # 8 p. 1255 - 1257
反应条件
1: Zn, 4 N HCl / ethanol / 1 h / Heating
2: conc. H2SO4, amylnitrite / ethanol / 0.67 h / 0 °C
3: H2(18)O / cyclohexane / 1.5 h / Heating
View Scheme
参考文献
Morimoto, Hiroshi; Hayashi, Nobuyoshi; Kawakami, Takeo
Chemische Berichte, 1981 , vol. 114, # 5 p. 1963 - 1966
反应条件
1: conc. H2SO4, amylnitrite / ethanol / 0.67 h / 0 °C
2: H2(18)O / cyclohexane / 1.5 h / Heating
View Scheme
参考文献
Morimoto, Hiroshi; Hayashi, Nobuyoshi; Kawakami, Takeo
Chemische Berichte, 1981 , vol. 114, # 5 p. 1963 - 1966
反应条件
bei der trocknen Destillation;
参考文献
de Laire; Tiemann
Chemische Berichte, 1893 , vol. 26, p. 2019
反应条件
oberhalb des Schmelzpunktes;
参考文献
de Laire; Tiemann
Chemische Berichte, 1893 , vol. 26, p. 2019
反应条件
1: 17 percent / K2CO3; CuO; pyridine / 6 h / Heating
2: 36 percent / H2 / Pd/C / ethyl acetate / 20 °C / atmospheric pressure
3: 11 mg / BBr3 / CH2Cl2 / 1.5 h / 20 °C
View Scheme
参考文献
Takenaka, Yukiko; Tanahashi, Takao; Nagakura, Naotaka; Hamada, Nobuo
Chemical and pharmaceutical bulletin, 2003 , vol. 51, # 7 p. 794 - 797
