sodium hydroxide in 1,4-dioxane; methanol 0.5 h;

in 1,4-dioxane; methanol; hexane

1: 75 percent / NaHCO3 / ethyl acetate; H2O / 0.5 h / 0 °C 2: 95 percent / K2CO3 / dimethylformamide / 1 h / Ambient temperature 3: 1) NaH / 1) DMF, 10 min, r.t., 2) DMF, 30 min, cooling 4: 100 percent / P2S5 / toluene / 2 h / Heating 5: 67 percent / 2 N NaOH / dioxane; methanol / 0.5 h View Scheme

1: 75 percent / NaHCO3 / ethyl acetate; H2O / 0.5 h / 0 °C 2: 95 percent / K2CO3 / dimethylformamide / 1 h / Ambient temperature 3: 1) NaH / 1) DMF, 10 min, r.t., 2) DMF, 30 min, cooling 4: 100 percent / P2S5 / toluene / 2 h / Heating 5: 67 percent / 2 N NaOH / dioxane; methanol / 0.5 h View Scheme

1: 1) NaH / 1) DMF, 10 min, r.t., 2) DMF, 30 min, cooling 2: 100 percent / P2S5 / toluene / 2 h / Heating 3: 67 percent / 2 N NaOH / dioxane; methanol / 0.5 h View Scheme

1: 95 percent / K2CO3 / dimethylformamide / 1 h / Ambient temperature 2: 1) NaH / 1) DMF, 10 min, r.t., 2) DMF, 30 min, cooling 3: 100 percent / P2S5 / toluene / 2 h / Heating 4: 67 percent / 2 N NaOH / dioxane; methanol / 0.5 h View Scheme

1: 100 percent / P2S5 / toluene / 2 h / Heating 2: 67 percent / 2 N NaOH / dioxane; methanol / 0.5 h View Scheme