4-(1H-1,2,4-三唑-1-基甲基)苯甲腈合成路线 （共 12 条）
反应条件
1: 4-cyanophenylmethyl hydrazine With hydrogenchloride in methanol; water T=10 - 15°C; 2: 5-azapyrimidine in methanol; water Reflux;
参考文献
WO2010/146391 A1, ;
Page/Page column 19 ;
反应条件
sodium triazolate (NAT) in isobutyramide T=-16 - 24°C; 0.5 - 2 h; Product distribution / selectivity;
参考文献
US2007/66831 A1, ;
Page/Page column 7-8 ;
反应条件
potassium carbonate; potassium iodide in acetone Inert atmosphereReflux;
参考文献
European Journal of Medicinal Chemistry, , vol. 46, # 9 p. 4010 - 4024
反应条件
1: 1H-1,2,4-triazol With caesium carbonate; potassium iodide in acetone T=55°C; 4 h; 2: 4-bromomethyl-benzonitrile in dichloromethane; acetone T=20°C; 5 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2007/107733 A1, ;
Page/Page column 13-14; 16-17 ;
反应条件
potassium carbonate; potassium iodide in acetone T=55°C; 8 h; Product distribution / selectivity;
参考文献
WO2005/47269 A1, ;
Page/Page column 7-8 ;
反应条件
in N,N-dimethyl-formamide T=10 - 30°C; 2.5 h;
参考文献
US2005/209294 A1, ;
Page/Page column 2 ;
反应条件
sodium hydroxide in dichloromethane; water 0.333333 h; Product distribution / selectivity;
参考文献
WO2005/47269 A1, ;
Page/Page column 7-8 ;
反应条件
in N,N-dimethyl-formamide T=-10 - 5°C; 0.5 h; Product distribution / selectivity;
参考文献
US2007/66831 A1, ;
Page/Page column 6-7; 9 ;
反应条件
potassium tert-butylate in tetrahydrofuran T=-15°C; 3 h; Product distribution / selectivity;
参考文献
CADILA HEALTHCARE LIMITED
Patent: WO2007/54964 A2, 2007 ;
Location in patent: Page/Page column 5; 11 ;
反应条件
potassium tert-butylate in tetrahydrofuran T=-15°C; 7 - 8 h; Product distribution / selectivity;
参考文献
NATCO PHARMA LIMITED; KOMPELLA, Amala kishan; RACHAKONDA, Sreenivas; ADIBHATLA KALI SATYA, Bhujanga rao; VENKAIAH CHOWDARY, Nannapaneni
Patent: WO2008/90565 A1, 2008 ;
Location in patent: Page/Page column 5 ;
