1: With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 1.5 h; 2: With ammonia in dichloromethane T=0°C; 2 h;

sulfuric acid in water

ammonia in tetrahydrofuran T=-50 - 20°C; 1.16667 h;

sodium hydroxide in water

1.1: 1,2-dichloro-ethane / 4 h / Heating 1.2: 90 percent / dioxane / 4 h / 0 - 20 °C 2.1: 84 percent / potassium bis(trimethylsilyl)amide; 18-crown-6 / tetrahydrofuran; toluene / 1.5 h / Heating 3.1: 89 percent / sodium hydride; (2,4-dinitro-phenyl)-hydroxylamine / tetrahydrofuran / 1.5 h / Heating View Scheme

1.1: 1,2-dichloro-ethane / 4 h / Heating 1.2: 90 percent / dioxane / 4 h / 0 - 20 °C 2.1: 84 percent / potassium bis(trimethylsilyl)amide; 18-crown-6 / tetrahydrofuran; toluene / 1.5 h / Heating View Scheme