1-环丙基-6,7-二氟-1,4-二氢-8-甲氧基-4-氧代-3-喹啉羧酸合成路线 （共 15 条）
反应条件
1: acetonitrile / 1 h / 70 - 80 °C / |Inert atmosphere; |Large scale 2: 1 h / 0 - 15 °C / |Large scale 3: triethylamine / acetonitrile / 12 h / 15 - 25 °C / pH 8.5 - 9.5 / |Large scale 4: acetonitrile; methanol / 5 h / 0 - 65 °C / |Large scale View Scheme
参考文献
Villasante, F. Javier; Gude, Lourdes; Fernandez, Sara P.; Alonso, Olga; Garcia, Elena; Cosme, Antonio
Organic Process Research and Development, 2008 , vol. 12, # 5 p. 900 - 903
反应条件
in dimethyl sulfoxide T=65 - 70°C; 6 - 8 h;
参考文献
SANDOZ AG
Patent: EP1992626 A1, 2008 ;
Location in patent: Page/Page column 10 ;
参考文献
Bayer Aktiengesellschaft
Patent: US5480879 A1, 1996 ;
反应条件
1.1: magnesium hydrooxide / acetonitrile / 1 h / 78 °C 1.2: 5 h / |Reflux 2.1: hydrogenchloride / water; ethanol / 6 h / 20 - 60 °C View Scheme
参考文献
F.I.S. - FABBRICA ITALIANA SINTETICI S.p.A.; Gottardo, Gianni; Padovan, Pierluigi; Osti, Sergio
Patent: US2013/59880 A1, 2013 ;
反应条件
1: |Alkaline conditions 2: hydrogenchloride View Scheme
参考文献
Lin, Zhiwei
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2014 , vol. 121, p. 254 - 258
