(1S,3R,5E,7E)-1,3-二-[(叔-丁基二甲基硅烷基)氧基]-9,10-开环孕甾-5,7,10-三烯-20-甲醛合成路线 （共 15 条）
反应条件
tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide in dichloromethane Molecular sieve;
参考文献
Gandara, Zoila; Perez, Manuel; Salomon, Debora G.; Ferronato, Maria J.; Fermento, Maria E.; Curino, Alejandro C.; Facchinetti, Maria M.; Gomez, Generosa; Fall, Yagamare
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 19 p. 6276 - 6279
反应条件
sodium hydrogencarbonate in ethanol 1.5 h; Heating;
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
sodium hydrogencarbonate in ethanol 1.5 h; Heating;
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C 2: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating 3: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating 4: imidazole / dimethylformamide / 1.5 h / 20 °C 5: liq. SO2 / diethyl ether / 0.5 h / Heating 6: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C 7: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C 2: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating 3: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating 4: imidazole / dimethylformamide / 1.5 h / 20 °C 5: liq. SO2 / diethyl ether / 0.5 h / Heating 6: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C 7: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: liq. SO2 / 0.5 h / Heating 2: 42 percent / imidazole / dimethylformamide / 1.5 h / 20 °C 3: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating 4: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating 5: imidazole / dimethylformamide / 1.5 h / 20 °C 6: liq. SO2 / diethyl ether / 0.5 h / Heating 7: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C 8: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: liq. SO2 / diethyl ether / 0.5 h / Heating 2: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C 3: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: imidazole / dimethylformamide / 1.5 h / 20 °C 2: liq. SO2 / diethyl ether / 0.5 h / Heating 3: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C 4: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating 2: imidazole / dimethylformamide / 1.5 h / 20 °C 3: liq. SO2 / diethyl ether / 0.5 h / Heating 4: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C 5: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: sodium hydrogen carbonate / aq. ethanol / 1.5 h / Heating 2: N-methylmorpholine N-oxide monohydrate, selenium dioxide / CH2Cl2; methanol / 0.83 h / Heating 3: imidazole / dimethylformamide / 1.5 h / 20 °C 4: liq. SO2 / diethyl ether / 0.5 h / Heating 5: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C 6: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
