(1S,3R,5E,7E)-1,3-二-[(叔-丁基二甲基硅烷基)氧基]-9,10-开环孕甾-5,7,10-三烯-20-甲醛合成路线 （共 15 条）
反应条件
1: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C 2: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
1: 1.) ozone 2.) PPh3 / 1.) CH2Cl2, MeOH, -60 deg C, 40 min. 2.) CH2Cl2, MeOH, -60 to 0 deg C 2: 90 percent / NaHCO3 / ethanol / 1.5 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
in methanol Heatingequilibrium; var. solv.; Product distribution;
参考文献
Tetrahedron, , vol. 43, # 20 p. 4609-4619
反应条件
sodium hydroxide; tetrabutylammomium bromide; water in toluene T=15 - 30°C; Product distribution / selectivity;
参考文献
LEO PHARMA A/S
Patent: WO2005/95336 A2, 2005 ;
Location in patent: Page/Page column 39-40 ;
反应条件
1: (2-cyclopropyl-2-oxo-ethyl)-phosphonic acid dimethyl ester With sodium hexamethyldisilazane in tetrahydrofuran T=-50°C; 4.16667 h; 2: (5E,7E)-(1S,3R,20S)-1,3-bislt;lt;(1,1-dimethylethyl)dimethylsilylgt;oxygt;-20-methyl-9,10-secopregna-5,7,10(19)-trien-21-al in tetrahydrofuran T=-50 - 20°C; Product distribution / selectivity;
参考文献
LEO PHARMA A/S
Patent: WO2005/95336 A2, 2005 ;
Location in patent: Page/Page column 40-41 ;
