反应条件
1: 64 percent / BF3*Et2O / CH2Cl2 / 16 h
2: 97 percent / 1N HCl / methanol / 24 h / 25 °C
3: 66 percent / H2O, paraformaldehyde / tetrahydrofuran / 2 h / Heating
4: TiCl4 / CH2Cl2; diethyl ether / 0.5 h / -78 °C
5: 10percent aq. NaOH / ethanol / 2 h / Heating
View Scheme
参考文献
Katz, Alan H.; Demerson, Christopher A.; Shaw, Chia-Cheng; Asselin, Andre A.; Humber, Leslie G.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1244 - 1250
