2,4-二氟-3-甲基苯甲酸合成路线 （共 7 条）
反应条件
1: 4-fluoro-2-fluorobenzoic acid With n-butyllithium; diisopropylamine in tetrahydrofuran T=-78°C; 2: methyl iodide in tetrahydrofuran T=-78 - 25°C; 3: With water; ammonium chloride in tetrahydrofuran
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BARVIAN, Kevin; BASARAB, Gregory, Steven; GOWRAVARAM, Madhusudhan, Reddy; HAUCK, Sheila, Irene; ZHOU, Fei
Patent: WO2010/43893 A1, 2010 ;
Location in patent: Page/Page column 99-100 ;
WO 2010/043893 A1
反应条件
hydrogenchloride; sodium hydroxide; bromine in 1,4-dioxane; water
反应条件
n-butyllithium in water
反应条件
1: 1-bromo-2,4-difluoro-3-methylbenzene With iodine; magnesium in tetrahydrofuran 1.08333 h; Reflux; 2: carbon dioxide in tetrahydrofuran 0.583333 h;
参考文献
US2005/54733 A1, ;
Page/Page column 4; 5 ;
反应条件
1: 3-Chloro-2,4-difluoro-bromobenzene in diethyl ether Cooling with acetone-dry ice; 2: n-butyllithium in hexane T=-65°C; 0.75 h; 3: carbon dioxide T=-65 - 20°C;
参考文献
US6348624 B1, ;
Page column 11 ;
反应条件
thionyl chloride; N,N-dimethyl-formamide in dichloromethane 70.0833 h; Heating / reflux;
参考文献
Hilgers, Petra; Marhold, Albrecht
Patent: US2005/54733 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
thionyl chloride in methanol T=60°C; 3 h; Cooling with ice;
参考文献
CONFLUENCE LIFE SCIENCES, INC.; SELNESS, Shaun R.; Devadas, Balekudru; Hockerman, Susan L.; Monahan, Joseph B.
Patent: US2013/143906 A1, 2013 ;
Location in patent: Paragraph 0324 ;
