4-氨基-5-氯-2-乙氧基-N-[[4-(4-氟苄基)-2-吗啉基]甲基]苯甲酰胺枸橼酸盐合成路线 （共 5 条）
反应条件
citric acid in water T=0°C; Heating / reflux;
参考文献
Richter Gedeon Vegyeszeti Gyar RT.
Patent: WO2003/106440 A2, 2003 ;
Location in patent: Page 10 ;
反应条件
1: (RS)-4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluoro-benzyl)-2-morpholinyl]-methyl}-benzamide dihydrochloride With sodium hydroxide in dichloromethane; water 0.5 h; Heating / reflux; 2: citric acid in water T=0°C; 0.5 h; Heating / reflux;
参考文献
Richter Gedeon Vegyeszeti Gyar RT.
Patent: WO2003/106440 A2, 2003 ;
Location in patent: Page 9-10 ;
反应条件
1: With sodium hydroxide in dichloromethane; water 2: With citric acid in water
参考文献
Richter Gedeon Vegyeszeti Gyar RT.
Patent: WO2003/106440 A2, 2003 ;
Location in patent: Page 10 ;
反应条件
T=80 - 110°C; 0.5 h; Product distribution / selectivity;
参考文献
RANBAXY LABORATORIES LIMITED; HASHMI, Mohd Salman; MADHRA, Mukesh Kumar; IF2
Patent: WO2011/107903 A1, 2011 ;
Location in patent: Page/Page column 11 ;
