4-苄基-2-(2-羟基乙基)吗啉合成路线 （共 5 条）
反应条件
lithium aluminium tetrahydride in diethyl ether 1 h; Ambient temperature;
参考文献
Dainippon Pharmaceutical Co., Ltd.
Patent: US4870074 A1, 1989 ;
反应条件
in water; acetone; toluene
参考文献
Yoshitomi Pharmaceutical Industries, Ltd.
Patent: US4889857 A1, 1989 ;
反应条件
1.1: triethylamine / water / 5.15 h / Reflux 1.2: 25 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 25 °C View Scheme
参考文献
LUPIN LIMITED; Shukla, Manojkumar Ramprasad; Chaudhari, Vinod Dinkar; Sayyed, Majid Bashir; Phadtare, Ramesh Dattatraya; Walke, Navnath Bajirao; Kulkarni, Sanjeev Anant; Palle, Venkata P.; Kamboj, Rajender Kumar
Patent: US2013/345213 A1, 2013 ;
反应条件
hydrogen; palladium 10 on activated carbon in methanol 8 h;
参考文献
LUPIN LIMITED; SHUKLA, Manojkumar, Ramprasad; CHAUDHARI, Vinod, Dinkar; SAYYED, Majid, Bashir; PHADTARE, Ramesh, Dattatraya; WALKE, Navnath, Bajirao; KULKARNI, Sanjeev, Anant; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar
Patent: WO2012/120476 A1, 2012 ;
Location in patent: Page/Page column 64 ;
WO 2012/120476 A1
反应条件
1: 42 percent / thionyl chloride / CHCl3 / 2.5 h / Heating 2: dimethylformamide / 5 h / Heating 3: hydrazine monohydrate / ethanol / 4 h / Heating View Scheme
参考文献
Kato; Morie; Hino; Kon; Naruto; Yoshida; Karasawa; Matsumoto
Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1406 - 1413
