6-溴甲基-3,4-二氢-2-甲基-喹唑啉-4-酮合成路线 （共 12 条）
反应条件
N-bromosuccinmide; dibenzoyl peroxide in chloroform 3 h; Heating;
参考文献
Cao, Sheng-Li; Feng, Yu-Ping; Jiang, Yu-Yang; Liu, Shi-Ying; Ding, Guo-Yu; Li, Run-Tao
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 7 p. 1915 - 1917
反应条件
N-bromosuccinmide; dibenzoyl peroxide in chloroform
反应条件
dibenzoyl peroxide in chloroform
反应条件
1: 73 percent / 2 h / 135 - 150 °C 2: 77 percent / N-bromosuccinimide; (PhCO)2O2 / CHCl3 / 3 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 7 p. 1915 - 1917
反应条件
2: 50 percent / 2,4-dibromo-5,5-dimethylhydantoin / benzoyl peroxide / CCl4; CHCl3 / 18 h / Heating; Irradiation View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 6 p. 1284 - 1289
反应条件
1: 89 percent / aq. NH3 / ethanol / 48 h / 20 °C 2: 76 percent / N-bromosuccinimide; benzoyl peroxide / CHCl3 / 3 h / Heating; UV-irradiation View Scheme
参考文献
Archiv der Pharmazie, , vol. 339, # 5 p. 250 - 254
反应条件
1: 74.2 percent / 2,6-lutidine / dimethylformamide / 55 - 60 °C 2: 88.6 percent / 1 N aq. NaOH / ethanol / 2 h / 20 °C View Scheme
参考文献
Synthetic Communications, , vol. 33, # 20 p. 3519 - 3526
反应条件
2,6-dimethylpyridine in N,N-dimethyl-formamide T=55 - 60°C;
参考文献
Cao, Sheng-Li; Wan, Rong; Feng, Yu-Ping
Synthetic Communications, 2003 , vol. 33, # 20 p. 3519 - 3526
反应条件
potassium carbonate; trifluoroacetic acid; calcium carbonate in N-methyl-acetamide; hexane; N,N-dimethyl acetamide; ethyl acetate; toluene
参考文献
US5444061 A1, ;
US5561133 A1, ;
反应条件
potassium carbonate; trifluoroacetic acid; calcium carbonate in N-methyl-acetamide; hexane; N,N-dimethyl acetamide; toluene
