4-(2-丙炔氨基)苯甲酸叔丁酯合成路线 （共 4 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide; toluene T=40°C; 24 h;
参考文献
ONYX PHARMACEUTICALS, INC.; KERSCHEN, James, Alan; BRIDGES, Alexander, James; DALZIEL, Sean, Mark; DAPREMONT, Olivier; KIM, Hyunjung; THOMPSON, Andrew, S.; ZELLER, James, Robert
Patent: WO2012/11939 A2, 2012 ;
Location in patent: Page/Page column 61-62 ;
反应条件
potassium carbonate in toluene T=50°C; 3.5 h;
参考文献
Bisset, Graham M. F.; Pawelczak, Krzysztof; Jackman, Ann L.; Calvert, A. Hilary; Hughes, Leslie R.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 859 - 866
反应条件
1: pyridine / 24 h / 0 - 20 °C / Inert atmosphere 2: potassium carbonate / N,N-dimethyl-formamide; toluene / 24 h / 40 °C View Scheme
反应条件
2,6-dimethylpyridine in N,N-dimethyl-formamide T=120°C; 5.5 h;
参考文献
Cancer Research Technology Limited
Patent: US6699861 B1, 2004 ;
Location in patent: Page column 17 ;
US 6699861 B1
