2-氨甲基-4-(4-氟苄基)吗啉合成路线 （共 9 条）
反应条件
hydrazine in ethanol 3 h; Heating / reflux;
参考文献
WO2003/106440 A2, ;
Page 10-11 ;
反应条件
hydrogenchloride 4 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 616 - 624
反应条件
1: H2, AcOH / 10percent Pd/C / ethanol / 60 °C 2: K2CO3, KI / butan-2-one / 17 h / Heating 3: 10percent HCl / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 616 - 624
反应条件
1: K2CO3, KI / butan-2-one / 17 h / Heating 2: 10percent HCl / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 616 - 624
反应条件
sulfuric acid 1.) 80 deg C, 3 h, 2.) 150 deg C, 2 h; Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 8 p. 1484 - 1492
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane 4 h; Ambient temperature; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 2 p. 616 - 624
反应条件
in chloroform 2 h; Ambient temperature; Yield given;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 8 p. 1484 - 1492
反应条件
1: 100 percent / 2N NaOH / CHCl3 / 3 h / 5 - 20 °C 2: CH2Cl2 / 4 h / Heating 3: toluene; methanol / 0.5 h / Heating 4: Et3N / CHCl3 / 18 h / Ambient temperature 5: 100 percent / H2 / 10percent Pd/C / ethanol; H2O / Ambient temperature View Scheme
参考文献
Kato, Shiro; Morie, Toshiya; Yoshida, Naoyuki
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 8 p. 1484 - 1492
