3,5-双(三氟甲基)苯基溴化镁合成路线 （共 12 条）
反应条件
magnesium in tetrahydrofuran Heating / reflux;
参考文献
US6350915 B1, ;
Example 2 ;
反应条件
in tetrahydrofuran; cyclohexane
反应条件
1: in tetrahydrofuran T=45°C; 6 h; 2: With sulfuric acid; water in tetrahydrofuran T=37°C; 1 h;
参考文献
MITENI S.P.A.
Patent: WO2005/35472 A1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
air in tetrahydrofuran T=25°C; P=12929 Torr; 0.0566667 h; Green chemistry;
参考文献
He, Zhi; Jamison, Timothy F.
Angewandte Chemie - International Edition, 2014 , vol. 53, # 13 p. 3353 - 3357
Angew. Chem., 2014 , vol. 126, # 13 p. 3421 - 3425,5
反应条件
in tetrahydrofuran T=-15 - 10°C; 1 h;
参考文献
Merck and Co., Inc.
Patent: US6350915 B1, 2002 ;
Location in patent: Example 2 ;
反应条件
in tetrahydrofuran T=-15 - 20°C;
参考文献
O Dalaigh, Ciaran; Connon, Stephen J.
Journal of Organic Chemistry, 2007 , vol. 72, # 18 p. 7066 - 7069
参考文献
Kelly,D.P.; Spear,R.J.
Australian Journal of Chemistry, 1978 , vol. 31, p. 1209 - 1221
反应条件
monobutyl butyl phosphonate; potassium hydride in diethyl ether 4 h;
参考文献
Casalnuovo, Albert L.; RajanBabu, T. V.; Ayers, Timothy A.; Warren, Timothy H.
Journal of the American Chemical Society, 1994 , vol. 116, # 22 p. 9869 - 9882
参考文献
Casalnuovo, Albert L.; RajanBabu, T. V.; Ayers, Timothy A.; Warren, Timothy H.
Journal of the American Chemical Society, 1994 , vol. 116, # 22 p. 9869 - 9882
反应条件
1.1: tetrahydrofuran / 72 h / |Reflux 2.1: hydrogenchloride / diethyl ether / 1 h / 0 - 20 °C 2.2: 2 h / -78 °C / |Reflux View Scheme
参考文献
Endo, Kohei; Hamada, Daisuke; Yakeishi, Sayuri; Shibata, Takanori
Angewandte Chemie - International Edition, 2013 , vol. 52, # 2 p. 606 - 610
Angew. Chem., 2013 , vol. 125, # 2 p. 634 - 638,5
