6-氟-7-哌嗪-1-甲基-4-氧-[1,3]硫氮杂环[3,2-a]-喹啉-3-羧酸合成路线 （共 14 条）
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide 5 h; Ambient temperature;
参考文献
Segawa, Jun; Kitano, Masahiko; Kazuno, Kenji; Matsuoka, Masato; Shirahase, Ichiro; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 25 p. 4727 - 4738
反应条件
N-ethyl-N,N-diisopropylamine; sodium bromide 1.) DMF, 303 K, 2 h, 2.) DMF, 304 K, 1 h; Yield given. Multistep reaction;
参考文献
Fujii; Nishida; Abiru; Yamamoto; Kise
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 11 p. 1872 - 1877
反应条件
potassium hydrogencarbonate in N,N-dimethyl-formamide T=30°C; 2 h; various periods of time (3 h); activation energy 29.1 kJ mol-1; Product distributionRate constant;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 67, # 5 p. 1419 - 1426
反应条件
potassium hydrogencarbonate 3 h; also in presence of DIPEA, car. concn. of substrates; Product distribution;
参考文献
Fujii; Nishida; Abiru; Yamamoto; Kise
Chemical and Pharmaceutical Bulletin, 1995 , vol. 43, # 11 p. 1872 - 1877
