1.1: pyridine / 10 h / 45 - 50 °C 2.1: NaH / tetrahydrofuran / 1 h / 20 °C 2.2: tetrahydrofuran / 4 h / 50 °C 3.1: p-TsOH; MeOH / CH2Cl2 / 8 h / 20 °C View Scheme
参考文献
Marx; Piantadosi; Noseda; Daniel; Modest
Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 858 - 863
1.1: pyridine / dimethylformamide / 2 h 2.1: pyridine / 10 h / 45 - 50 °C 3.1: NaH / tetrahydrofuran / 1 h / 20 °C 3.2: tetrahydrofuran / 4 h / 50 °C 4.1: p-TsOH; MeOH / CH2Cl2 / 8 h / 20 °C View Scheme
参考文献
Liu, Dong-Zhou; Morris-Natschke, Susan L.; Kucera, Louis S.; Ishaq, Khalid S.; Thakker, Dhiren R.
Journal of Pharmaceutical Sciences, 1999 , vol. 88, # 11 p. 1169 - 1174
1: 2-bromoethyl phosphorodichloridate; (+/-)-3-octadecanamido-2-ethoxy-1-propanol Alkylation; 2: trimethylamine With water in chloroform; N,N-dimethyl-formamide; isopropyl alcohol Amination;
参考文献
Liu, Dong-Zhou; Morris-Natschke, Susan L.; Kucera, Louis S.; Ishaq, Khalid S.; Thakker, Dhiren R.
Journal of Pharmaceutical Sciences, 1999 , vol. 88, # 11 p. 1169 - 1174
