1.1: tetrahydrofuran / 5 h / 5 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 2.2: 80 °C 3.1: dichloromethane / 18 h / 20 °C View Scheme
1.1: thionyl chloride; N,N-dimethyl-formamide / 16.33 h / 40 - 72 °C / |Reflux 2.1: tetrahydrofuran / 5 h / 5 °C 3.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 3.2: 80 °C 4.1: dichloromethane / 16 h / 20 °C 4.2: 18 h / 20 °C View Scheme
1.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C 2.1: potassium tert-butylate / N,N-dimethyl-formamide / 2 h / 20 °C 2.2: 20 - 80 °C 3.1: dichloromethane / 16 h / 20 °C 3.2: 18 h / 20 °C View Scheme
