6-氟-7-哌嗪-1-甲基-4-氧代-[1,3]硫氮杂环[3,2-a]喹啉-3-羧酸乙酯合成路线 （共 11 条）
反应条件
in N,N-dimethyl-formamide T=10 - 55°C; 9.16667 h;
参考文献
CIPLA LIMITED; PATHI, Srinivas Laxminarayan; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra; CHINIMILLI, Venugopalarao; CURTIS, Philip Anthony
Patent: WO2012/1357 A1, 2012 ;
Location in patent: Page/Page column 21-22 ;
反应条件
in N,N-dimethyl-formamide Ambient temperature;
参考文献
Segawa, Jun; Kitano, Masahiko; Kazuno, Kenji; Matsuoka, Masato; Shirahase, Ichiro; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 25 p. 4727 - 4738
反应条件
1: 1.) KOH / 1.) dioxane, RT, 30 min., 2.) 4 deg C, 15 h 2: 2.22 g / K2CO3 / dimethylformamide / 1 h / 70 °C 3: 0.350 g / PPE / 1.5 h / 80 °C 4: 84 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: ethyl chloroformate, triethylamine / CHCl3 / 3.5 h / Ambient temperature 2: 1.) KOH / 1.) dioxane, RT, 30 min., 2.) 4 deg C, 15 h 3: 2.22 g / K2CO3 / dimethylformamide / 1 h / 70 °C 4: 0.350 g / PPE / 1.5 h / 80 °C 5: 84 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: 0 °C 2: ethyl chloroformate, triethylamine / CHCl3 / 3.5 h / Ambient temperature 3: 1.) KOH / 1.) dioxane, RT, 30 min., 2.) 4 deg C, 15 h 4: 2.22 g / K2CO3 / dimethylformamide / 1 h / 70 °C 5: 0.350 g / PPE / 1.5 h / 80 °C 6: 84 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: 47 percent / K2CO3, KI / dimethylformamide / 0.5 h / 105 - 110 °C 2: 84 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: 99 percent / 35percent HCl / ethanol / 2 h / Ambient temperature 2: 47 percent / K2CO3, KI / dimethylformamide / 0.5 h / 105 - 110 °C 3: 84 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: 0.350 g / PPE / 1.5 h / 80 °C 2: 84 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: 58 percent / diphenyl ether / 5 h / 240 °C 2: 99 percent / 35percent HCl / ethanol / 2 h / Ambient temperature 3: 47 percent / K2CO3, KI / dimethylformamide / 0.5 h / 105 - 110 °C 4: 84 percent / dimethylformamide / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: With water; potassium hydroxide T=80 - 85°C; 1 h; 2: With acetic acid in water T=20°C; pH=6.5 - 7; 1 h;
参考文献
CIPLA LIMITED; PATHI, Srinivas Laxminarayan; RAO, Dharmaraj Ramachandra; KANKAN, Rajendra; CHINIMILLI, Venugopalarao; CURTIS, Philip Anthony
Patent: WO2012/1357 A1, 2012 ;
Location in patent: Page/Page column 22 ;
