6,7-二氟-1-甲基-4-氧代-4H-[1,3]噻嗪[3,2-a]并喹啉-3-羧酸乙酯合成路线 （共 19 条）
反应条件
potassium carbonate; potassium iodide in N,N-dimethyl-formamide T=105 - 110°C; 0.5 h;
参考文献
Segawa, Jun; Kitano, Masahiko; Kazuno, Kenji; Matsuoka, Masato; Shirahase, Ichiro; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 25 p. 4727 - 4738
反应条件
sodium acetate in tetrahydrofuran 4 h; Heating;
参考文献
Matsuoka; Segawa; Makita; Ohmachi; Kashima; Nakamura K.-; Hattori; Kitano; Kise
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 1.) KOH / 1.) dioxane, RT, 30 min., 2.) 4 deg C, 15 h 2: 2.22 g / K2CO3 / dimethylformamide / 1 h / 70 °C 3: 0.350 g / PPE / 1.5 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: ethyl chloroformate, triethylamine / CHCl3 / 3.5 h / Ambient temperature 2: 1.) KOH / 1.) dioxane, RT, 30 min., 2.) 4 deg C, 15 h 3: 2.22 g / K2CO3 / dimethylformamide / 1 h / 70 °C 4: 0.350 g / PPE / 1.5 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: 0 °C 2: ethyl chloroformate, triethylamine / CHCl3 / 3.5 h / Ambient temperature 3: 1.) KOH / 1.) dioxane, RT, 30 min., 2.) 4 deg C, 15 h 4: 2.22 g / K2CO3 / dimethylformamide / 1 h / 70 °C 5: 0.350 g / PPE / 1.5 h / 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: 99 percent / 35percent HCl / ethanol / 2 h / Ambient temperature 2: 47 percent / K2CO3, KI / dimethylformamide / 0.5 h / 105 - 110 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: 58 percent / diphenyl ether / 5 h / 240 °C 2: 99 percent / 35percent HCl / ethanol / 2 h / Ambient temperature 3: 47 percent / K2CO3, KI / dimethylformamide / 0.5 h / 105 - 110 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 25 p. 4727 - 4738
反应条件
1: 92 percent / m-CPBA / CH2Cl2 / 4 h / Ambient temperature 2: 67 percent / 48 h / 70 °C 3: 79 percent / xylene / 3 h / Heating 4: 93 percent / Et3N / CHCl3 / 1 h / 0 °C 5: 79 percent / sulfuryl chloride / hexane / 1.5 h / Heating 6: 69 percent / NaOAc / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 1.) K2CO3 / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 0 deg C, 3 h 2: 53 percent / NH3 / ethanol / 18 h / 80 °C 3: 58 percent / KHCO3 / dimethylformamide / 24 h / 80 °C 4: 93 percent / Et3N / CHCl3 / 1 h / 0 °C 5: 79 percent / sulfuryl chloride / hexane / 1.5 h / Heating 6: 69 percent / NaOAc / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
