6,7-二氟-1-甲基-4-氧代-4H-[1,3]噻嗪[3,2-a]并喹啉-3-羧酸乙酯合成路线 （共 19 条）
反应条件
1: 1.) NaH 2: 92 percent / m-CPBA / CH2Cl2 / 4 h / Ambient temperature 3: 67 percent / 48 h / 70 °C 4: 79 percent / xylene / 3 h / Heating 5: 93 percent / Et3N / CHCl3 / 1 h / 0 °C 6: 79 percent / sulfuryl chloride / hexane / 1.5 h / Heating 7: 69 percent / NaOAc / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 67 percent / 48 h / 70 °C 2: 79 percent / xylene / 3 h / Heating 3: 93 percent / Et3N / CHCl3 / 1 h / 0 °C 4: 79 percent / sulfuryl chloride / hexane / 1.5 h / Heating 5: 69 percent / NaOAc / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 93 percent / Et3N / CHCl3 / 1 h / 0 °C 2: 79 percent / sulfuryl chloride / hexane / 1.5 h / Heating 3: 69 percent / NaOAc / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 79 percent / xylene / 3 h / Heating 2: 93 percent / Et3N / CHCl3 / 1 h / 0 °C 3: 79 percent / sulfuryl chloride / hexane / 1.5 h / Heating 4: 69 percent / NaOAc / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 53 percent / NH3 / ethanol / 18 h / 80 °C 2: 58 percent / KHCO3 / dimethylformamide / 24 h / 80 °C 3: 93 percent / Et3N / CHCl3 / 1 h / 0 °C 4: 79 percent / sulfuryl chloride / hexane / 1.5 h / Heating 5: 69 percent / NaOAc / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 79 percent / sulfuryl chloride / hexane / 1.5 h / Heating 2: 69 percent / NaOAc / tetrahydrofuran / 4 h / Heating View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 34, # 6 p. 1773 - 1779
反应条件
1: 84 percent / dimethylformamide / Ambient temperature 2: 88 percent / KOH / 2-methyl-propan-2-ol; H2O / 1 h / 50 - 60 °C View Scheme
参考文献
Segawa, Jun; Kitano, Masahiko; Kazuno, Kenji; Matsuoka, Masato; Shirahase, Ichiro; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 25 p. 4727 - 4738
反应条件
1: 84 percent / dimethylformamide / Ambient temperature 2: 88 percent / KOH / 2-methyl-propan-2-ol; H2O / 1 h / 50 - 60 °C 3: 62 percent / KHCO3 / dimethylformamide / 5 h / Ambient temperature View Scheme
参考文献
Segawa, Jun; Kitano, Masahiko; Kazuno, Kenji; Matsuoka, Masato; Shirahase, Ichiro; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 25 p. 4727 - 4738
反应条件
in N,N-dimethyl-formamide Ambient temperature;
参考文献
Segawa, Jun; Kitano, Masahiko; Kazuno, Kenji; Matsuoka, Masato; Shirahase, Ichiro; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 25 p. 4727 - 4738
