N-(2,6-二甲基苯基)氯乙酰胺合成路线 （共 36 条）
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide T=30 - 35°C; 18 h;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2008/312247 A1, 2008 ;
Location in patent: Page/Page column 31-32 ;
反应条件
in methanol 5 h; Reflux;
参考文献
SHODHANA LABORATORIES LIMITED; GIRIDHAR, Thota; SRINIVASULU, Gudipati; SRINIVASA RAO, Kotaru
Patent: WO2010/23687 A2, 2010 ;
Location in patent: Page/Page column 17 ;
反应条件
1: methanol / 25 °C / Reflux; Large scale reaction 2: acetone / 0 - 58 °C / Large scale reaction View Scheme
参考文献
Madivada, Lokeswara Rao; Anumala, Raghupathi Reddy; Gilla, Goverdhan; Kagga, Mukkanti; Bandichhor, Rakeshwar
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1660 - 1664
反应条件
in methanol T=25°C; RefluxLarge scale reaction;
参考文献
Organic Process Research and Development, , vol. 16, # 5 p. 748 - 754
反应条件
tetrabutyl ammonium fluoride in water T=20 - 60°C; 3 h;
参考文献
Kommi, Damodara N.; Kumar, Dinesh; Chakraborti, Asit K.
Green Chemistry, 2013 , vol. 15, # 3 p. 756 - 767
反应条件
N-ethyl-N,N-diisopropylamine in ethanol
参考文献
Blackburn, Brent K.; Zablocki, Jeff; Elzein, Elfatih; Nudelman, Grigory
Patent: US2001/44541 A1, 2001 ;
反应条件
in ethanol 3 h; Reflux;
参考文献
ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD.; SHANGHAI KUOIKEE LABORATORIES CO., LTD.; Shi, Mingfeng; Li, Dan; Xu, Ling
Patent: US2013/90475 A1, 2013 ;
Location in patent: Paragraph 0029; 0030 ;
参考文献
Zablocki, Jeff; Elzein, Elfatih; Blackburn, Brent K.; Marquart, Tim; Ibrahim, Prabha N.; Palle, Venkata P.
Patent: US2001/41704 A1, 2001 ;
反应条件
in water T=80 - 110°C; 7 h;
参考文献
Kommi, Damodara N.; Kumar, Dinesh; Chakraborti, Asit K.
Green Chemistry, 2013 , vol. 15, # 3 p. 756 - 767
反应条件
potassium carbonate in water; acetonitrile T=20°C; 25 h;
参考文献
NEKTAR THERAPEUTICS AL, CORPORATION
Patent: WO2009/54916 A2, 2009 ;
Location in patent: Page/Page column 41; 43 ;
