5-氯-3-甲基-1-苯基吡唑合成路线 （共 24 条）
反应条件
nitric acid; acetic anhydride T=0 - 20°C; 4 h;
参考文献
Purohit, Meena K.; Chakka, Sai Kumar; Scovell, Iain; Neschadim, Anton; Bello, Angelica M.; Salum, Norue; Katsman, Yulia; Bareau, Madeleine C.; Branch, Donald R.; Kotra, Lakshmi P.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 9 p. 2739 - 2752
反应条件
1: 84 percent / POCl3 / 7 h / 70 °C 2: 92 percent / NaN3; tetrabutylammonium bromide / dimethylsulfoxide / 24 h / 20 °C View Scheme
参考文献
Barreiro, Eliezer J.; Camara, Celso A.; Verli, Hugo; Brazil-Mas, Leonora; Castro, Newton G.; Cintra, Wagner M.; Aracava, Yasco; Rodrigues, Carlos R.; Fraga, Carlos A. M.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 7 p. 1144 - 1152
反应条件
carbon disulfide; aluminium trichloride
T=50 - 55°C;
参考文献
Michaelis; Rojahn
Chemische Berichte, 1917 , vol. 50, p. 746
参考文献
Michaelis; Rojahn
Chemische Berichte, 1917 , vol. 50, p. 746
