3,4-二甲氧基苯乙酮合成路线 （共 188 条）
反应条件
1: potassium hydroxide / ethanol; water / 2.5 h / Reflux 2: iodine / 1.4 h / 100 - 110 °C / Neat (no solvent) View Scheme
参考文献
Sashidhara, Koneni V.; Kumar, Manoj; Kumar, Abdhesh
Tetrahedron Letters, 2012 , vol. 53, # 18 p. 2355 - 2359
反应条件
sodium hydroxide in ethanol 24 h; Ambient temperature;
参考文献
Silva, Vanessa Dutra; Stambuk, Boris Ugarte; Nascimento, Maria da Graca
Journal of Molecular Catalysis B: Enzymatic, 2010 , vol. 63, # 3-4 p. 157 - 163
反应条件
1: sodium methylate / tetrahydrofuran / 8 h / 20 °C 2: hydroxylamine hydrochloride / methanol / 3 h / |Reflux 3: sodium hydroxide / tetrahydrofuran / 1 h / 60 °C View Scheme
参考文献
Kamal, Ahmed; Tamboli, Jaki R.; Vishnuvardhan; Adil; Nayak, V. Lakshma; Ramakrishna
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 273 - 280
反应条件
1: -15 °C / anschliessendes Erhitzen mit Schwefel bis auf 150grad 2: aq.-ethanolic hydrochloric acid / an Blei-Elektroden View Scheme
参考文献
Kindler; Peschke
Archiv der Pharmazie (Weinheim, Germany), 1932 , vol. 270, p. 353,359
反应条件
sodium hydride in toluene; mineral oil
参考文献
Chen, Yi-Fong; Lin, Yi-Chien; Huang, Po-Kai; Chan, Hsu-Chin; Kuo, Sheng-Chu; Lee, Kuo-Hsiung; Huang, Li-Jiau
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 17 p. 5064 - 5075
反应条件
1: sodium methylate / tetrahydrofuran / 8 h / 20 °C 2: acetic acid; hydrazine hydrate / 1 h / |Reflux 3: hydroxylamine hydrochloride; sodium hydroxide / methanol / 1 h / 80 °C View Scheme
参考文献
Kamal, Ahmed; Tamboli, Jaki R.; Vishnuvardhan; Adil; Nayak, V. Lakshma; Ramakrishna
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 273 - 280
反应条件
1: ethanol; aq. NaOH solution 2: methanol; acetic acid 3: acetic acid; sulfuric acid 4: aq.-ethanolic NaOH-solution 5: amalgamated zinc; aqueous hydrochloric acid; toluene / weiteres Reagenz: Essigsaeure 6: POCl3 View Scheme
参考文献
Richardson et al.
Journal of the Chemical Society, 1937 , p. 835,839
反应条件
1: 45.4 percent / bromine / CHCl3 / 0.33 h / Heating 2: 97 percent / K2CO3 / acetone View Scheme
参考文献
Pardini, Vera L.; Smith, Carmen Z.; Utley, James H. P.; Vargas, Reinaldo R.; Viertler, Hans
Journal of Organic Chemistry, 1991 , vol. 56, # 26 p. 7305 - 7313
反应条件
1: bromine / chloroform / 4 h / 0 °C / |Reflux 2: sodium carbonate / N,N-dimethyl-formamide / 3 h / 25 °C 3: sodium tetrahydroborate / tetrahydrofuran; water / 0.33 h / |Reflux 4: [bis(acetoxy)iodo]benzene; Fe(TAML)Li; diphenylether; water / acetone / 1 h / 25 °C / |Green chemistry 5: 25 °C View Scheme
参考文献
Napoly, Francois; Jean-Gerard, Ludivine; Goux-Henry, Catherine; Draye, Micheline; Andrioletti, Bruno
European Journal of Organic Chemistry, 2014 , vol. 2014, # 4 p. 781 - 787
反应条件
1: ethanol; aq. NaOH solution 2: methanol; acetic acid 3: acetic acid; sulfuric acid 4: aq.-ethanolic NaOH-solution 5: amalgamated zinc; aqueous hydrochloric acid; toluene / weiteres Reagenz: Essigsaeure View Scheme
参考文献
Richardson et al.
Journal of the Chemical Society, 1937 , p. 835,839
