3,4-二甲氧基苯乙酮合成路线 （共 188 条）
反应条件
sodium hydroxide in ethanol
参考文献
The United States of America as represented by the Department of Health, Education and Welfare
Patent: US4014885 A1, 1977 ;
反应条件
1: bromine / chloroform / 4 h / 0 °C / |Reflux 2: sodium carbonate / N,N-dimethyl-formamide / 3 h / 25 °C 3: sodium tetrahydroborate / tetrahydrofuran; water / 0.33 h / |Reflux 4: [bis(acetoxy)iodo]benzene; Fe(TAML)Li; diphenylether; water / acetone / 1 h / 25 °C / |Green chemistry View Scheme
参考文献
Napoly, Francois; Jean-Gerard, Ludivine; Goux-Henry, Catherine; Draye, Micheline; Andrioletti, Bruno
European Journal of Organic Chemistry, 2014 , vol. 2014, # 4 p. 781 - 787
反应条件
hydrogenchloride in ethanol T=80°C; 18 h;
参考文献
MERCK PATENT GMBH; YU, Henry; RICHARDSON, Thomas E.; FOGLESONG, Robert James; DESELM, Lizbeth Celeste; GOUTOPOULOS, Andreas
Patent: WO2013/6308 A2, 2013 ;
Location in patent: Page/Page column 133 ;
反应条件
1: Nysted reagent With bis(cyclopentadienyl)titanium dichloride in tetrahydrofuran T=40°C; 0.5 h; Inert atmosphere; 2: 1-(3,4-dimethoxyphenyl)ethan-1-one in tetrahydrofuran T=20°C; 5 h; Inert atmosphere;
参考文献
Haahr, Adam; Rankovic, Zoran; Hartley, Richard C.
Tetrahedron Letters, 2011 , vol. 52, # 23 p. 3020 - 3022
参考文献
Confalone, Pat N.; Huie, Edward M.
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 7175 - 7178
反应条件
1: triphenyl-methyl-phosphonium iodide With n-butyllithium in tetrahydrofuran; hexane T=0°C; Wittig Olefination; 0.5 h; 2: 1-(3,4-dimethoxyphenyl)ethan-1-one in tetrahydrofuran; hexane T=20°C; Wittig Olefination; 24 h;
参考文献
Gong, Wanchun; Liu, Yun; Xue, Jijun; Xie, Zhixiang; Li, Ying
Chemistry Letters, 2012 , vol. 41, # 12 p. 1597 - 1599
反应条件
1) Et2O, reflux, 30 min, 2) 170 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Schmidt, Arthur H.; Kircher, Gunnar; Spring, Mathias; Hendriok, Markus W.; Kuenz, Christian
Advanced Synthesis and Catalysis, 1997 , vol. 339, # 6 p. 564 - 574
反应条件
1: 0.2 g / hydrobromic acid / 3 h / Heating 2: 1.8 g / K2CO3 / KI / acetone / 6 h / Heating View Scheme
参考文献
Ahluwalia, V. K.; Kapur, Kanchan; Manchanda, Saroj
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 3 p. 186 - 188
反应条件
piperidine; sulfur T=180 - 200°C; Erhitzen des erhaltenen Reaktionsprodukts mit wss. Schwefelsaeure;
参考文献
Burger; Fitchett
Journal of the American Chemical Society, 1952 , vol. 74, p. 3415
反应条件
sodium hypochlorite; sodium hydroxide in water Haloform Reaction; 2 h; TemperatureConcentration;
参考文献
Organic Process Research and Development, , vol. 3, # 5 p. 341 - 346
