3-(三氟甲基)-1-甲基-1H-吡唑-4-甲酸合成路线 （共 12 条）
反应条件
1: 3-piperidin-1-yl-acrylic acid methyl ester; trifluoroacetyl fluoride With potassium fluoride in toluene T=-30 - 20°C; 4 h; 2: methylhydrazine in toluene T=-50 - 20°C; 3 h;
参考文献
BASF SE
Patent: US2011/40096 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
lithium hydroxide hydrate in tetrahydrofuran T=70°C; pH=5; 2 h;
参考文献
Wu, Zhibing; Hu, Deyu; Kuang, Jiqing; Cai, Hua; Wu, Shixi; Xue, Wei
Molecules, 2012 , vol. 17, # 12 p. 14205 - 14218
反应条件
1: 4-bromo-1-methyl-3-(trifluoromethyl)pyrazole With tert.-butyl lithium in diethyl ether; pentane T=-75°C; 0.0833333 h; 2: carbon dioxide Further stages.;
参考文献
Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt
European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920
反应条件
potassium hydroxide in ethanol 4 h; Ambient temperature;
参考文献
Okada, Etsuji; Masuda, Ryoichi; Hojo, Masaru
Heterocycles, 1992 , vol. 34, # 4 p. 791 - 798
反应条件
water; sodium hydroxide in methanol T=75°C; 4 h; Product distribution / selectivity;
参考文献
MITSUI CHEMICALS AGRO, INC.
Patent: EP2128139 A1, 2009 ;
Location in patent: Page/Page column 25 ;
反应条件
1: 65 percent / bromine; iron powder / 4 h / 100 °C 2: 85 percent / tert-butyllithium / pentane; diethyl ether / 0.08 h / -75 °C View Scheme
参考文献
European Journal of Organic Chemistry, , # 17 p. 2913 - 2920
反应条件
1: sodium hydride / N,N-dimethyl-formamide / 20.33 h / 0 - 20 °C 2: lithium hydroxide hydrate / tetrahydrofuran / 2 h / 70 °C / pH 5 View Scheme
参考文献
Molecules, , vol. 17, # 12 p. 14205 - 14218
反应条件
1: hydrazine hydrate / methanol / 3 h / 80 °C 2: sodium hydride / N,N-dimethyl-formamide / 20.33 h / 0 - 20 °C 3: lithium hydroxide hydrate / tetrahydrofuran / 2 h / 70 °C / pH 5 View Scheme
参考文献
Molecules, , vol. 17, # 12 p. 14205 - 14218
反应条件
1: 76 percent / CF3COOH, H2O / CHCl3 / 3 h / Ambient temperature 2: 93 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 34, # 4 p. 791 - 798
反应条件
1: 97 percent / acetonitrile / 1 h / Ambient temperature 2: 93 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 34, # 4 p. 791 - 798
