in methanol T=35°C; 120 h;

1: NaHCO3, Na2S2O4 / H2O / 20 - 35 °C 2: diethyl ether; ethanol / -20 °C / overnight 3: 83 percent / methanol / 120 h / 35 °C View Scheme

1: diethyl ether; ethanol / -20 °C / overnight 2: 83 percent / methanol / 120 h / 35 °C View Scheme

1: 89 percent / NH3(l) / 3 h / -33 °C 2: 89 percent / Na2S2O4 / H2O / 24 h / Heating 3: 32 percent / acetic anhydride / 2 h / Heating 4: 87 percent / xanthine oxidase (AXO) / 120 h / 4N NaOH, potassium phosphate buffer, pH 8.0 View Scheme