N-(4-氯-6-甲氧基苯基)-2,2-二甲基丙酰胺合成路线 （共 10 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 20°C; 16 h;
参考文献
Ichikawa, Masanori; Yokomizo, Aki; Itoh, Masao; Haginoya, Noriyasu; Sugita, Kazuyuki; Usui, Hiroyuki; Terayama, Koji; Kanda, Akira
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5207 - 5224
反应条件
TEA in dichloromethane T=0 - 25°C; Acylation; 3 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 19 p. 2805 - 2810
反应条件
hydrogenchloride; triethylamine in ethanol-tetrahydrofuran; ethanol; dichloromethane
参考文献
DuPont Pharmaceuticals Company
Patent: US5874430 A1, 1999 ;
反应条件
hydrogenchloride; triethylamine in ethanol-tetrahydrofuran; ethanol; dichloromethane
参考文献
Bristol-Myers Squibb Pharma Company
Patent: EP929533 B1, 2003 ;
反应条件
1: SnCl2; EtOH / Heating 2: NEt3 / CH2Cl2 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
1.1: s-BuLi / tetrahydrofuran / -20 - 0 °C 2.1: aq. HCl / 1,2-dimethoxy-ethane / Heating 3.1: BBr3 / CH2Cl2 4.1: imidazole / dimethylformamide / 0 °C 5.1: 76 percent / tetrahydrofuran; hexane / -20 °C 6.1: i-Pr2NEt / toluene / -25 - 20 °C 7.1: n-Bu4NF / tetrahydrofuran 7.2: chiral phase SCFC View Scheme
参考文献
Markwalder, Jay A.; Christ, David D.; Mutlib, Abdul; Cordova, Beverly C.; Klabe, Ronald M.; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 619 - 622
反应条件
1: s-BuLi / tetrahydrofuran / -20 - 0 °C 2: aq. HCl / 1,2-dimethoxy-ethane / Heating 3: BBr3 / CH2Cl2 4: imidazole / dimethylformamide / 0 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 5 p. 619 - 622
反应条件
hydrogenchloride; sec.-butyllithium in tetrahydrofuran; ethylene glycol dimethyl ether; cyclohexane
参考文献
Bristol-Myers Squibb Pharma Company
Patent: EP929533 B1, 2003 ;
反应条件
1: s-BuLi / tetrahydrofuran / -20 - 0 °C 2: aq. HCl / 1,2-dimethoxy-ethane / Heating View Scheme
参考文献
Patel, Mona; Ko, Soo S.; McHugh Jr., Robert J.; Markwalder, Jay A.; Srivastava, Anurag S.; Cordova, Beverly C.; Klabe, Ronald M.; Erickson-Viitanen, Susan; Trainor, George L.; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 19 p. 2805 - 2810
反应条件
1: s-BuLi / tetrahydrofuran / -20 - 0 °C 2: aq. HCl / 1,2-dimethoxy-ethane / Heating 3: BBr3 / CH2Cl2 4: imidazole / dimethylformamide / 0 °C 5: 76 percent / tetrahydrofuran; hexane / -20 °C 6: i-Pr2NEt / toluene / -25 - 20 °C View Scheme
参考文献
Markwalder, Jay A.; Christ, David D.; Mutlib, Abdul; Cordova, Beverly C.; Klabe, Ronald M.; Seitz, Steven P.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 5 p. 619 - 622
